Methotrexate is our next oncology drug available for Bayesian forecasting and therapeutic drug monitoring! Six models covering Osteosarcoma, Acute Lymphoblastic Leukemia (ALL), Lymphoma, and Rheumatoid Arthritis patients are now available. We hope you find it useful in your everyday practice. New Features
CrCl History is now available within Lab Results instead of a single CrCl entry! Just like Scr History, the history of CrCl values will be taken into account during PK simulation, dynamically adjusting drug clearance according to the Exact CrCl at each time point.
Multi-site License is available for institutions to access cross-site patient cases and evaluate Advanced Analytics by site. Please contact our team at email@example.com to get started on this!
A new warning set in Drug Monitoring alerts users to increase hydration when a level 12 hours after a dose is above a certain threshold.
Dialysis History tooltip is now available to provide clearer guidance and insights into the dialysis workflow! To view, direct to “How do I use Dialysis History?” within Dialysis History.
Therapeutic Target improvements
In addition to the existing Peak targeting capabilities, our latest update now allows users to conveniently assess both the “Next Peak” and the “Last Peak” in the Dosing Recommendations! “Last Peak” is defined as the predicted peak of the most recent dose within Dosage History.
To further enhance the Therapeutic Target functionality, we have incorporated a “daily max dose warning” feature. This important addition will alert users when the prescribed dosage exceeds the recommended maximum limit on a daily basis.
You asked and we listened! Auto-save was our most requested feature in our 2022 User Survey and we are happy to announce it is now available on the platform. Keep your peace of mind and continue counting on PrecisePK to automate your workflow, helping you bring the best out of your clinical judgment.
PrecisePK will auto-save 5 seconds after your last valid action.
Visit Settings to enable auto-save for yourself or set it to your institution in Admin Settings.
Sanford Guide is now accessible within PrecisePK for those with an active subscription! Now, subscribers can enable quick access to drug references and be provided with the most updated guidelines on anti-infective agents and associated diseases. Sanford Guide subscribers can access Sanford Guide through hyperlinks under the Patient Summary and Population PK Source.
1. New design, same workflow! While PrecisePK may look a little different than before, the functionality of PrecisePK remains exactly the same. Continue dosing seamlessly with PrecisePK with all the models and features that you know and love. 2. Updated PrecisePK’s UI by standardizing all styling, colors, and text to a new design system. 3. New user interface now features improved color contrast, keyboard interactions, and navigation for better viewing and experience.
1. Added "mg/kg" tooltip for Vancomycin dose recommendations. Hover over Vancomycin dose values to show a Tooltip that converts the dose form "mg" to "kg". 2. Added a Tooltip to Dosage Analytics in Dosage History to provide definitions for all the AUC and Level values to provide clarity into Dosage Analytics' outputs.
1. Fixed a bug where selecting a drug in Advanced Search would not filter out the other non-selected drugs. 2. Fixed a bug where “Individual PK From Last Visit” was not populating from previous cases and General Population PK Parameters remained. 3. Fixed a bug on Advanced Analytics where selecting any non-English language would show placeholder values instead of numbers. 4. Fixed a bug where the users would lose access to the application, but experience a delay before being redirected to the login page.
Tacrolimus is now available for Bayesian forecasting and therapeutic drug monitoring! Two models covering the adult kidney-transplant population are available to ensure accurate target attainment in patients undergoing hematopoietic cell transplants (HCTs). We hope you find it useful in your everyday practice.
1. Introducing the highly anticipated Therapeutic Analytics! This feature categorizes and analyzes how well your patient population achieves your desired Therapeutic Target. Based on the results, patient populations will be categorized into Subtherapeutic, Therapeutic and Supratherapeutic groups.
2. Users can view and assess these results through Advanced Analytics.
3. Therapeutic Status Overview provides a breakdown of the number of patients in each therapeutic status, and in different Percentages of Time in Therapeutic Range (%TTR).
4. Therapeutic Target Insights analyzes the trend of the defined therapeutic target value over a time interval or dose interval.
5. AKI Analytics is now a part of the Advanced Analytics page.
1. Revamped Current AUC projection and added Future AUC prediction under Dosing Recommendation module to better support clinical workflow. AUIC24 Range updated to Future AUC Prediction, which predicts the next AUC24 after your most recent dose.
2. Route option now available in Therapeutic Target Input.
1. Added both units --- hr*mg/L and min*umol/L for AUC. Now you can select the one that best supports your workflow!
2. Added AUC cumulative for 2-day regimen as a Therapeutic Target, alongside AUC cumulative for 4-day regimen. The projected AUC range under Dosing Recommendation takes account of the entire dosing regimen.
Optimization - Dialysis Module is now showing the Total Clearance
1. Thanks to our users' feedback, we brought back the Current AUIC24 calculation to display on the Therapeutic Target card! You can also click the eye icon next to it to highlight the corresponding area on the Serum Level Graph.
2. Added an alert banner on top of the Steady Stage page that reminds users that Steady State Analysis does not take account of Dialysis History.
3. When deleting, archiving or unarchiving a patient, now all cases associated with that patient will be shown in the Edit History table for Admin users.
4. When selecting from a Dropdown menu (e.g. drug library), now you can search and select options by typing on your keyboard.
5. Optimized Date and Time input with auto-tabbing.
6. Increased decimal accuracy of Nomogram (vancomycin) output to from 0 decimal to 1 decimal place.
1. Model Analytics allows you to compare your patient population’s General Population Models and Bayesian Individual Models for Vancomycin using linear regression. (More drug models to be expected in the future)
2. Validate each model easily by selecting a predefined statistic: R-Squared, Mean Squared Error, and Normalized Root Mean Square Deviation.
3. This feature is only available for current customers, please reach out to firstname.lastname@example.org if you’d like to learn more.
We’ve made some changes to the archive and delete feature in PrecisePK. Now administrators can archive, unarchive or delete patient profiles and patient cases on Admin > Patient Database page. Deleted records cannot be recovered. Regular users can only archive patient profiles and cases on the Home page search module.
Redesigned input tooltips on Patient Information and Steady State page to improve user experience in readability.
Overhauled the interaction for date and time input fields to improve user experience to be more predictable and consistent.
We added two new Vancomycin dialysis models (Westra 2019, and Claisse 2019) to account for adult patients on IHD/CRRT. The revamped dialysis module features a new interactive workflow and improved user experience. Vancomycin dialytic clearance, also known as CL_RRT (Previously labeled as Kt/V) will be calculated by the program based on your input. To use these dialysis models, select appropriate factors in the Extra Drug Factors and the program will automatically select the best fitting model.
New Feature - Continuous Infusion Now Available for Vancomycin
Now you can view detailed Vancomycin Model Informationwithin the program. A quick model summary will pop up when you hover over different model options. Click on the icon next to the model name in the Patient Summary, and you will see detailed model information in a separate popup window.
We added a quick link to the interactive User Manual within the program (under your user profile icon). You will find detailed instructions, video tutorials, and common FAQs – everything you need to get you started with PrecisePK.
Busulfan is now available for Bayesian forecasting and therapeutic drug monitoring! Multiple models available covering different patient populations and drug routes to ensure accurate target attainment in patients undergoing hematopoietic cell transplants (HCTs). We hope you find it useful in your everyday practice.
New Feature - Enhanced User Interface & User Experience
1. Introducing patient Home page
Now you can create a new patient, resume patient cases you last worked on, or search from the patient database all from one page.
We addedthe Recently Active Patient Cases card so you can quickly pick up the patient case you left off without searching for it.
2. We updated to a simpler navigation structure so you can find everything you need from the top menu bar. If you are a system admin or IAM, use the application switcher to navigate to different modules.
3. We modified Lab Results Card so now it’s easier to view equations and sources for the calculation
4. New Info Sidebar on the Drug Monitoring and Steady-State Analysis page - now you can reference all the relevant case information (patient summary and PK parameters) on the left side of the screen while you work through the case.
Introducing quick select and snap feature to the Serum Level Graph! For patients with longer dosing history, the program will default to select the last 72 hrs of the graphing. You also have the option to quickly select from default views or customize your selection by dragging the side of the gray highlight box.
Resolved a few known bugs (thanks to user feedback!)
Improved server interruption handling to support optimal performance. Now you will be given the option to reconnect or restart the app with auto restored data when server interruption occurs.
PrecisePK automatically selects the proper Bayesian models based on your patients’ characteristics. Now, you will also be able to view and select different population models in the dropdown next to the Population PK Parameters, providing greater transparency and user control
When you open the new dropdown, you will be greeted with some new models covering a range of different populations. With the recent release of the 2020 IDSA Vancomycin Guideline, we want to ensure we are fully compliant with these new standards while offering the precision you come to expect from PrecisePK!
In the Extra Drug Factors, you can now select between three different BMI classes of obesity to further refine the Population model for any obese patients. Hover over each obesity class to see how the program changes the model.
Based on user feedback, now you can toggle whether the program provides a recommended loading or maintenance dose at your determined date/time. If you like a dosage recommendation, just click “Add Dose” and it will populate under Dosage History. Automatically update target date and time whenever Dosage History updates.
New Notes Window - Compact popup panel that you can access on any page. Leave behind notes for staff coordination and collaboration, and quickly filter through messages via component tags to find relevant information.
Centralized Alerts - With some feedback from our users, we placed all of the Toxicity Alerts in one place for easy viewing and a more pleasant user experience. See the centralized alerts in the top-right corner under the “Bell” icon.
Auto-sort Drug List - Based on your suggestion, we are making it a little easier for you to select your most used drugs! The drug selection dropdown will now auto-sort based on your use frequency, placing your most used drugs near the top for easy selection.
Resolved some known bugs.
Improved UI styling consistency.
Added tooltips throughout the program for quick reference.
Improved backend structure to support optimal performance.
This new workflow for the Drug Monitoring page offers flexible dosing recommendations that will help you meet and maintain your desired target.
Additionally, the new dose rounding feature allows instant predictions of efficacy through normal distributions. This new Drug Monitoring page is a dynamic and practical tool for building an effective dose regimen.
Now you can access Product Tours about upcoming new features, which automatically start when you navigate to its respective page for the first time. Product Tours are designed to walk you through workflow changes or larger feature updates, with added visuals for better explanations.
With this new feature, see the properties of each individual dose and its effects on your patient’s serum levels and AUC. Navigate to the Drug Monitoring page, enter a Dosage History record, and see these analytics by clicking the “...” on the record. With more data at your fingertips, it’s easier than ever to analyze the efficacy of your dosage regimen -- dose by dose.
Throughout the program, a small orange “!” may appear. These are our new Toxicity Warnings, which will pop up whenever PrecisePK detects a potentially toxic dose or level. Detailed explanations are provided when you click on these warnings. You can also view these warnings for individual doses under Dosage History in the Dose Analytics window.
Added amputation selection in the patient information card. Now users can select and choose the degree of amputation to further customize PK parameters.
On the Patient Info screen, you are able to adjust the patient’s PK parameters by selecting relevant drug factors or manually entering in the parameters to account for special populations. Now, easily account for amputees with our new Amputation selection, which is placed next to the Drug selection. Select the type of amputation this patient has to automatically adjust the PK parameters and hover over each type of amputation to see how the program adjusts for it.
New Drug Factors - Obesity and Pharmacogenomics
In addition to the new Amputation selection, we added a couple more drug factors to our list. Account for obese patients and patients with specific genes easily by selecting these new factors.
What you are seeing now is our new Changelog feature, which describes any new features, updates, or fixes that are now in the program. We will let you know what has changed whenever you log in for the first time after a recent release, but feel free to check out what’s new by clicking on the [NEW] icon near the top.